The impact of local anesthetic volume and concentration on pain during prostate biopsy: a prospective randomized trial.

PURPOSE: To evaluate the effect of equivalent doses of local anesthetic administered at different concentrations and volumes on pain scores in patients undergoing prostate biopsy. PATIENTS AND METHODS: This study was a single-center, randomized trial. A total of 120 patients were randomized into two groups with 60 patients in each group. In group 1, 2.5 mL of 2% lidocaine (low volume-high concentration) and in group 2, 5 mL of 1% lidocaine (high volume-low concentration) was injected just lateral to the junction between the prostate base and seminal vesicle on each side under ultrasonographic guidance. Patients were given an 11 point visual analog scale (VAS) to evaluate the level of pain encountered during transrectal ultrasonographic (TRUS) probe insertion, injection of the local anesthetic, and the biopsy procedure. RESULTS: In both groups, TRUS probe insertion was the most painful stage of the procedure. With regard to local anesthetic injection, the VAS pain score was significantly lower in group 1 (1.56 vs. 2.41, P=0.001). Concerning sampling of the prostate, group 1 had a significantly lower VAS pain score compared with group 2 (1.71 vs. 2.48, P=0.008). Neither major complications nor side effects related to local anesthetic absorption occurred in both groups. CONCLUSION: Low volume-high concentration lidocaine administration provides superior analgesia compared with high volume-low concentration lidocaine during transrectal biopsy of the prostate.

Effects of soft palate implants on acoustic characteristics of voice and articulation.

OBJECTIVE: To evaluate the effects of soft palate implants on voice and articulation. STUDY DESIGN: Prospective case series. METHODS: Male subjects (n=23) diagnosed with mild obstructive sleep apnea and/or habitual snoring underwent acoustic analysis with the Multidimensional Voice Program (Kay Multi-Speech Model 3700 Advanced Version; Kay Elemetrics [KayPentax], Lincoln Park, NJ) before and 8 weeks after insertion of palatal implants to determine the effects of soft palate implants on voice and articulation. Sustained vowels (/a/e/u/o/i/) and phonetically balanced carrier sentences were used for acoustic analyses. Parameters measured were fundamental frequency (F0), jitter, shimmer, noise-to-harmonics ratio, Voice Turbulence Index, Soft Phonation Index, degree of voiceless, degree of voice breaks and peak amplitude variation, first formant (F1) and second formant (F2) frequencies, and voice onset time (VOT). F1 and F2 for each vowel were determined using linear predictive analysis on a spectrogram. VOT was measured for the palatal consonant /k/ and the dental consonant /t/ on a wideband spectrogram from a carrier sentence segment that contained a syllable with a stop consonant. RESULTS: No statistically significant difference was detected in F0, F1, F2, or other MDVP parameters before and after implantation. Average VOT values measured for /t/ were not significantly different. On the other hand, average VOT values of /k/ were found to be significantly shorter. CONCLUSIONS: Implant insertion had no significant effect on MDVP parameters, F0, F1, or F2. On the other hand, articulation as a function of velar region seemed to be affected because VOT values of velar /k/ were changed.